((17α , 20E) -17, 20-[ (1-methoxyethyleneidene) Bis - (oxy) ]-3-Oxo-19-Norpregna-4, 20-Diene-21-Carbo Sarms Yk11

What is YK11?(17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), which the myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor &lpa

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What is YK11?
(17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), which the myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor (AR) partial agonist. 
YK11 is a selective androgen receptor modulator (SARM), which activates AR without the N/C interaction. In this study, we further investigated the mechanism by which YK11 induces myogenic differentiation of C2C12 cells. The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody.
Myogenic differentiation is in reference to the products ability to block myostatin. Myostatin inhibition has been a really popular movement since the ban of most prohormones as it looks to be a relatively unexplored area for muscle growth and fat loss. There are currently a lot of claims about mystatin inhibition, but not so much factual data on these products. YK11 will have similar affects to DHT (possibly more potent) without the negatives of DHT. What this means is that the product will most likely be suppressive and require a post cycle, but not cycle support. It also won't have androgenic side affects like hair loss, acne, etc. The increase in follistatin caused by YK11 will act as an antagonist to mystatin (it will block myostatin) as well as the anabolic growth properties of YK11.
How it works?
Animal Research:
In direct comparison to to LGD-4033 as the reference for assay upon animal models of anabolism and androgenicity, YK-11 demonstrated higher efficacy withing anabolic parameters and lesser androgenicity at equivalent dosages.
It induces muscle cells to make more follistatin which is a strong myostatin inhibitor. Myostatin (also known as growth differentiation factor 8, is a myokine (protein) produced by muscle cells that acts on muscle cells to inhibit myogenesis. Myogenesis is muscle cell growth and differentiation. Research through the years show that when you block myostatin, it allows for significantly more muscle mass. So in research myostatin inhibitors are researched to find cures for muscle diseases.
We expect YK11 to be more potent than SARM LGD in terms of overall growth and feel. At this time, we expect this to be the strongest SARM on the market at a regular dosing. While suppression can occur, we expect this product to have low androgenic properties and can be used by both men and women. From our experience with SARMs, we find there are less losses of on-cycle results than pro-hormones, although typically not as potent. We do expect this product to have similar results as a moderately dosed Halodrol, without the alpha-male/androgenic feelings while on it.
Dosages and Suggestion
Recommended maximum dose YK11 is require dosages of 2.0-5.0mg b.i.d. in males and 0.5mg-2mg b.i.d. in females to achieve optimal effects in humans for the noted indications.

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Tam*oxif*en citrate/No*lvad*ex
CAS: 54965-24-1
 
Raws Name(hot sell)Abbr
Test* BaseTB
Test* Enan TE
Test* Cyp TC
Test* Iso TI
Test* Deca TD
Test* Unde TU
Test* Prop TP
Test* Phenylp TPP
Test* ace TA
Sus250 (Test mixed)s250
4-Chlorotest ace /
4-Chlorodehydromethylt /
  
Bold B
Bold ace BA
Bold* Unde*  EQBU
Bold Cyp BC
  
Nand N
Na*nd*  De*ca ND
Nand  Cy NC
Nand  Unde  NU
Nand*  Phenylp N*P*P
  
Oxan /Anav OA
Oxyme  /Anadr Oxy
Stano /WinstrST
Metand /DanabDB
Tr*en* ace (Revalor-H)TBA
Tr*en* Enan TBE
Methe ace*tate MA
Methe enan*thateME
Dros*tano*l EnanDE
Drosta*nolo* Prop*ionate(Maste)DP
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Peptides NameSpec
GHR*-65mg
GHR*-25mg 
Ipamor*lin 2mg 5mg
M*lanotan I10mg 
M*-II10mg
CJ*-1295 (DAC)2mg 
CJ*-1295 (without DAC)2mg 
MG* (IG*-1 EC)2mg
P*-14110mg
S*rmorelin 2mg 
P*G-MGF 2mg 
DS*IP2mg 5mg
sel*ank 2mg
Oxyt*ocin2mg 
Gonado*relin 2mg 
Tripto*relin 100ug
GH*RH 2mg 
Tesa*morelin 2mg
Fra*g(176-191)2mg 5mg 
Hexareli*n2mg 5mg 10mg
Thymos*in Beta 4 (TB4) Model: TB-5002mg 5mg 10mg
H*H blue/red/green/yellow to*ps   10iu
Hy*getropin/Jin*tropin/Kig*tropin/Rip*tropin 10iu 
H*C*G5000iu 
  
Sarms 
MK2866841205-47-8
SR90091379686-30-2
RAD1401182367-47-0
MK67715972-10-0
S4401900-40-1
YK11431579-34-9
LGD-40331165910-22-4
GW-501516317318-70-0






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